Reumatologi - HÖK och kompendium - Region Norrbotten

ANA, dsDNA och ENA screen - Region Kalmar Län

HER2-positiv och ER-  Diffuse cutaneous systemic sclerosis exhibits production of anti topoisomerase I antibodies (anti Scl 70)
and skin lesion affects also proximal parts of the  Anti-topoisomerase antibodies (ATA) are autoantibodies directed against topoisomerase and found in several diseases, most importantly scleroderma. Diseases with ATA are autoimmune disease because they react with self-proteins. They are also referred to as anti-DNA topoisomerase I antibody (anti-topo I). Topoisomerase inhibitors are chemical compounds that block the action of topoisomerases, which are broken into two broad subtypes: type I topoisomerases (TopI) and type II topoisomerases (TopII). Anti-Scl-70 antibody is present in a significant subset of patients with SLE. For this subset, it offers a good correlate of disease activity and suggests increased risk for pulmonary hypertension and nephritis. Topoisomerase I Antibodies This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. All lanes : Anti-Topoisomerase II beta/TOP2B antibody (ab72334) at 0.04 µg/ml Lane 1 : Whole cell lysate from Hela cells at 50 µg Lane 2 : Whole cell lysate from Hela cells at 15 µg Lane 3 : Whole cell lysate from Hela cells at 5 µg Lane 4 : Whole cell lysate from 293T cells at 50 µg Developed using the ECL technique.

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A nice clip i found on the mechanisms of action of topoisomerase 1 and 2 Mouse Anti-Human Topoisomerase IIα (Ki-S1) (1mg) Anti-Topoisomerase II Antibody, clone KiS1 is a Mouse Monoclonal Antibody for detection of Topoisomerase II also known as Ki-S1 & has been validated in FC, WB, ICC, IHC, IHC(P). - Find MSDS or SDS, a COA, data sheets and more information. The patients with MPC and PIP joints flexion contractures had higher mean value of anti-topo I abs titers (53.718 ±50.977 vs 8.127 ± 8.915, P < 0.0001) than did those with no contractures. Furthermore, the titers of anti-topoisomerase I antibody positively correlated with the flexion contractures (r … Anti-topoisomerase antibodies (ATA) are autoantibodies directed against topoisomerase and found in several diseases, most importantly scleroderma.Diseases with ATA are autoimmune disease because they react with self-proteins. They are also referred to as anti-DNA topoisomerase I antibody (anti-topo I). Contents. Epitopes and subtypes anti-topoisomerase I antibody: An autoantibody found in the serum of patients with progressive systemic sclerosis, silicosis, and systemic lupus erythematosus. Higher levels of the antibody correlate with worsening kidney, lung, and skin disease.

Reumatologi - kliniska riktlinjer - DocPlus - Region Uppsala

Konferenser. Herben, V., et al.: Anti-Cancer Drugs, 9, 411 (1998), Hsiang, Y., et al. K-antagonist kan förstärka anti-koaguleringseffekt.

636648 Produktnamn: Ms Anti-Hu Topoisomerase IIa Ki-S1

SCO-101 in combination with an anti-cancer agent for the treatment of cancer. Specific combination therapies include: SCO-101 + specific topoisomerase I  Tillsätt 1 μg av anti-immunglobulin G (IgG), anti-histon H3 (som en ng super plasmid pSupFG1 DNA helt med ett pl Vaccinia Topoisomeras I  Topoisomeras och helikas: Öppnar upp dubbelhelixen. ”Single strand binding proteins”: Binder till enkelsträngat DNA som temporärt bildas och skyddar det från  Scl-70-antigenen har identifierats som ett cellformigt enzym, DNA topoisomeras I (30). Antikroppar mot Scl-70 har rapporterats hos upp till 56 procent av  Topoisomeras 1: Scl-70. MHCII. CITR.

protein produced by the immune system in response to the presence in the body of antigens: foreign proteins or polysaccharides such as bacteria, bacterial Explanation of anti-topoisomerase I antibody Anti-Topoisomerase II alpha + Topoisomerase II beta antibody [EPR5377] browse more products. Anti-alpha 1 Fetoprotein antibody [EP1016Y] | ab52940; Response to Anti-Topoisomerase II Agents Ian G. Cowell * and Caroline A. Austin Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, Tyne and Wear NE2 4HH, UK; E-Mail: caroline.austin@ncl.ac.uk * Author to whom correspondence should be addressed; E-Mail: ian.cowell@ncl.ac.uk; Type II DNA topoisomerases have the ability to generate a transient DNA double-strand break through which a second duplex can be passed; an activity essential for DNA decatenation and unknotting. Topoisomerase poisons stabilize the normally transient topoisomerase-induced DSBs and are potent and widely used anticancer drugs. However, their use is associated with therapy-related secondary Sep 18, 2017 Significance of Anti-Topoisomerase I Antibodies in Routine Clinical Testing. Anne E Tebo1, Robert L. Schmidt2 and Tracy M. Frech3,  Antitopoisomerase I antibodies (ATA) and anticentromere antibodies (ACA) are important diagnostic markers of SSc. Each of these autoantibodies can be found in  Anti-Topoisomerase I-DNA Covalent Complexes Antibody, clone 1.1A is an antibody against Topoisomerase I-DNA Covalent Complexes for use in  Anti-topoisomerase I (anti-Scl-70) antibodies in patients with systemic lupus erythematosus. Hélène A Elicha Gussin, Georghe P. Ignat, John Varga, Marius  Western blot analysis of whole cell lysates probed with topoisomerase II alpha antibody followed by detection with Goat anti Mouse HRP conjugated (1/10,000,   This is an antibody to a the enzyme topoisomerase I. Anti-Scl 70 may be found in the following conditions: pre-scleroderma; diffuse cutaneous systemic sclerosis  400 products Listed below are anti-Topoisomerase II antibodies from multiple suppliers.
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Systemic sclerosis, Anti‐topoisomerase I antibody, Modified Rodnan total skin thickness score, Autoantibody level, Longitudinal study. Systemic sclerosis (SSc) is a multisystem disorder of connective tissue characterized by excessive fibrosis in the skin and various internal organs. INTRODUCTION: In the present study, the detection of anti-topoisomerase I (anti-topo I) autoantibodies was evaluated for diagnosis and risk assessment of systemic sclerosis (SSc) patients in a well characterized large monocentric cohort. Using immunoprecipitation assays and enzyme-linked immunoassay (ELISA), anti-topoisomerase I Ab was detected in 53 SSc patients who visited Kanazawa University Hospital between 2001 and 2010. In these patients, the association between serum anti-topoisomerase I Ab levels measured with ELISA and clinical features were compared using univariate analysis and multiple regression analysis. English. Scl-70 - Scleroderma-70 ab, SCL-70 extractable nuclear Antibody, SCL-70 extractable nuclear Ab, Scl-70 - Scleroderma-70 antibody, Topoisomerase-1 antibody, Topoisomerase-1 antibody (substance) Spanish.

MHCII. CITR. Anti-CCP (ACPA): 95% specificitet för RA, 60-80% sensitivitet. ACPA (anti-CCP): Anti Citrullinated Protein Antibody. Klassificeras utifrån verkningsmekanism, delas in i 1) Alkylerande medel och platinaföreningar 2) Topoisomeras-hämmare 3) Antimetaboliter 4) Mitoshämmare (SLE), Sjögrens syndrom, systemisk skleros och myosit/anti-syntetassyndrom. Topoisomeras-1 (Scl-70), centromerantigen B (CENP-B), och Jo-1 (samtliga  RF, anti-CCP, extraartikulära symptom etc. eller förekomst av centromer-antikroppar eller anti-Scl-70 2.
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The presence of anti-SCL-70 (anti-topoisomerase) antibodies is highly specific to the diagnosis of diffuse scleroderma, while the presence of anti-centromere antibodies is highly specific to the diagnosis of limited scleroderma. The presence of Scl-70 antibodies (also referred to as topoisomerase I, topo-I or ATA) is considered diagnostic for systemic sclerosis (SSc). Scl-70 antibodies alone are detected in about 20 percent of SSc patients and are associated with the diffuse form of the disease, which may include specific organ involvement and poor prognosis. Different antibodies, called anti-topoisomerase and RNA polymerase III, are often present in people who have diffuse systemic sclerosis. Thus, the diagnosis of systemic sclerosis is based on all of the information doctors gather, including symptoms, physical examination results, and all test results.

Reduced DNA topoisomerase II activity and drug-induced DNA cleavage Non-steroidal anti-inflammatory drugs to potentiate chemotherapy effects: from lab to  Identifiering av den nya TAA som ett fragment av humant DNA-topoisomeras I. ( A ) Western blot-analys av anti-SCL-70-autoantikroppreaktionerna med fyra  av B Lytsy · Citerat av 4 — Data från det europeiska organet för övervakning av anti- biotikaförbrukning till minskad affinitet för målenzymerna DNA-gyras och DNA-topoisomeras IV sker i. Studies on the efficacy of potent anti-HIV-1 therapy on virologicaland Topoisomerase II and drug resistance in leukemic cells . Zhou  av B Janicke · 2017 · Citerat av 15 — of the anti‐cancer drug etoposide, a well‐established topoisomerase inhibitor that causes DNA damage and leads to programmed cell death. Antinuclear antikroppar och anti-topoisomerase I antikroppar var starkt positiva. En högupplösande datortomografi (CT) genomsökning av lungor avslöjade  Topoisomeras II-hämmande cytostatika såsom etoposid, teniposid och antracykliner [158,.
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Abstrakt 3007 ning av mål-proteinet och ökad anti-tumoral effekt. En för- av Trastuzumab kopplat till en topoisomeras-. Reduced DNA topoisomerase II activity and drug-induced DNA cleavage Non-steroidal anti-inflammatory drugs to potentiate chemotherapy effects: from lab to  Identifiering av den nya TAA som ett fragment av humant DNA-topoisomeras I. ( A ) Western blot-analys av anti-SCL-70-autoantikroppreaktionerna med fyra  av B Lytsy · Citerat av 4 — Data från det europeiska organet för övervakning av anti- biotikaförbrukning till minskad affinitet för målenzymerna DNA-gyras och DNA-topoisomeras IV sker i. Studies on the efficacy of potent anti-HIV-1 therapy on virologicaland Topoisomerase II and drug resistance in leukemic cells . Zhou  av B Janicke · 2017 · Citerat av 15 — of the anti‐cancer drug etoposide, a well‐established topoisomerase inhibitor that causes DNA damage and leads to programmed cell death. Antinuclear antikroppar och anti-topoisomerase I antikroppar var starkt positiva. En högupplösande datortomografi (CT) genomsökning av lungor avslöjade  Topoisomeras II-hämmande cytostatika såsom etoposid, teniposid och antracykliner [158,.